I haven't been able to give up Twitter or Instagram, but removing Facebook and Facebook Messenger from all of my devices has been an absolute joy and I don't regret it at all. Sure, maybe some long lost family members would have a harder time getting in touch, but like... whatever, Facebook is evil.
I haven't yet deleted my account yet, though. I suppose that should be a thing I do soon.
Next to go: Instagram (aka Instagram by Facebook)
Twitter: maybe? As long as I stay off the trending tabs, there's no issue - might have to do some research into alternative apps that let you not look at those things so much.